- ordinary tiredness
Kidney problems can cause a deep kind of fatigue. One reason is that diseased kidneys may make less erythropoietin, a hormone that tells the body to make red blood cells. Fewer red blood cells can mean anemia, and anemia can leave you weak, pale,
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and worn out even after a full night of sleep.
This is not the usual “I stayed up too late” tired. It is more like feeling winded after walking a short distance, needing to sit down